T'ai Chi Chih Medical Studies

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The effect of an 8-week tai chi exercise program on physical functional performance in middle-aged women.

Zacharia S1, Taylor EL2, Hofford CW2, Brittain DR3, Branscum PW2.

J Appl Gerontol 2015;34:573–589

Tai Chi Chih: an exercise option for older adults.
Schaller KJ.
J Gerontol Nurs. 1996 Oct;22(10):12-7.

Tai Chi Chih Compared With Cognitive Behavioral Therapy for the Treatment of Insomnia in Survivors of Brest Cancer: A Randomized, Partially Blinded, Noninferiority Trial

Irwin MR1, Olmstead R1, Carrillo C1, Sadeghi N1, Nicassio P1, Ganz PA1, Bower JE1. All authors: University of California Los Angeles, Los Angeles, CA.

Journal of Clinical Oncology 2017; JCO2016710285

Improved sleep quality in older adults with insomnia reduces biomarkers of disease risk: Pilot results from a randomized controlled comparative efficacy trial 

Carroll JE1, Seeman TE2, Olmstead R3, Melendez G3, Sadakane R3, Bootzin R4, Nicassio P5, Irwin MR6

Psychoneuroendocrinology 2015;55:184–192.

Cognitive behavioral therapy and tai chi reverse cellular and genomic markers of inflammation in late life insomnia: A randomized controlled trial

Irwin MR1, Olmstead R2, Breen EC2, Witarama T3, Carrillo C3, Sadeghi N3, Arevalo JM4, Ma J4, Nicassio P2, Bootzin R5, Cole S4.

Biol Psychiatry 2015; 78:721–829.

Cognitive behavioral therapy vs. tai chi for late life insomnia and inflammatory risk: A randomized controlled

comparative efficacy trial 

Irwin MR, Olmstead R, Carrillo C, Sadeghi N, Breen EC, Witarama T, Yokomizo M, Lavretsky H, Carroll JE, Motivala SJ, Bootzin R, Nicassio P.

Sleep 2014; 37:1543–1552

Improved Sleep Quality in Older Adults with Moderate Sleep Complaints: A Randomized Controlled Trial of Tai Chi Chih
Michael R. Irwin, MD: Richard Olmstead, PhD; Sarosh J. Motivala, PhD

Sleep 2008;31:1001–1008.

Tai Chi Chih Compared With Cognitive Behavioral Therapy for the Treatment of Insomnia in Survivors of Breast Cancer: A Randomized, Partially Blinded, Noninferiority Trial.

Irwin MR1, Olmstead R1, Carrillo C1, Sadeghi N1, Nicassio P1, Ganz PA1, Bower JE1. 

All authors: University of California Los Angeles, Los Angeles, CA

Journal of Clinical Oncology 2017

Blood pressure, salivary cortisol, and inflammatory cytokine outcomes in senior female cancer survivors enrolledin a tai chi chih randomized controlled trial. 

Campo RA1, Light KC, O'Connor K, Nakamura Y, Lipschitz D, LaStayo PC, Pappas LM, Boucher KM, Irwin MR, Hill HR, Martins TB, Agarwal N, Kinney AY.

Author information: Program on Integrative Medicine, Department of Physical Medicine & Rehabilitation, University of North Carolina at Chapel Hill, CB# 7200, Chapel Hill, NC, 27599-7200, USA, rebecca_campo@med.unc.edu.

J Cancer Surviv 2015; 9:115–125

Tai chi, cellular inflammation, and transcriptome dynamics in breast cancer survivors with insomnia: A randomized controlled trial.

Michael R. Irwin,Richard Olmstead, Elizabeth C. Breen, Tuff Witarama, Carmen Carrillo, Nina Sadeghi, Jesusa M. G. Arevalo, Jeffrey Ma, Perry Nicassio, Patricia A. Ganz, Julienne E. Bower, and  Steve Cole

J Natl Cancer Inst Monogr 2014; 50:295–301.

Feasibility and acceptability of a tai chi chih randomized controlled trial in senior female cancer survivors.

Rebecca A. Campo, PhD, Kathleen O’Connor, MS, Kathleen C. Light, PhD, Yoshio Nakamura, PhD, David Lipschitz, PhD, Paul C. LaStayo, PhD, PT, Lisa Pappas, MS, Kenneth Boucher, PhD, Michael R. Irwin, MD, Neeraj Agarwal, MD, and  Anita Y. Kinney, PhD

Integr Cancer Ther 2013;12:464–474

Cognitive behavioral therapy and tai chi reverse cellular and genomic markers of inflammation in late life insomnia: A randomized controlled trial. 

Irwin MR1, Olmstead R2, Breen EC2, Witarama T3, Carrillo C3, Sadeghi N3, Arevalo JM4, Ma J4, Nicassio P2, Bootzin R5, Cole S4.

Biol Psychiatry 2015; 78:721–829.

Blood pressure, salivary cortisol, and inflammatory cytokine outcomes in senior female cancer survivors enrolled in a tai chi chih randomized controlled trial.

Campo RA1, Light KC, O'Connor K, Nakamura Y, Lipschitz D, LaStayo PC, Pappas LM, Boucher KM, Irwin MR, Hill HR, Martins TB, Agarwal N, Kinney AY.

J Cancer Surviv 2015; 9:115–125.

Tai chi, cellular inflammation, and transcriptome dynamics in breast cancer survivors with insomnia: A randomized controlled trial. Michael R. Irwin, Richard Olmstead, Elizabeth C. Breen, Tuff Witarama, Carmen Carrillo, Nina Sadeghi, Jesusa M. G. Arevalo, Jeffrey Ma, Perry Nicassio, Patricia A. Ganz, Julienne E. Bower, and  Steve Cole

J Natl Cancer Inst Monogr 2014; 50:295–301.

Mitigating cellular inflammation in older adults: A randomized controlled trial of tai chi chih. 

Michael R. Irwin, M.D1 and  Richard Olmstead, Ph.D1

Am J Geriatr Psychiatry 2012;20:764–772.

Black DS, Irwin MR, Olmstead R, Ji E, Crabb Breen E, Motivala SJ. Tai chi meditation effects on nuclear factor-κB signaling in lonely older adults: a randomized controlled trial. Psychother Psychosom. 2014;83(5):315-7. doi: 10.1159/000359956. Epub 2014 Aug 6. PMID: 25116908; PMCID: PMC4165547. https://pubmed.ncbi.nlm.nih.gov/25116908/

Blood pressure, salivary cortisol, and inflammatory cytokine outcomes in senior female cancer survivors enrolled in a tai chi chih randomized controlled trial.

Campo RA1, Light KC, O'Connor K, Nakamura Y, Lipschitz D, LaStayo PC, Pappas LM, Boucher KM, Irwin MR, Hill HR, Martins TB, Agarwal N, Kinney AY.

J Cancer Surviv 2015; 9:115–125

Reducing stress and enhancing general well being of teachers using t’ai chi chih movements. 

Richard A. Detert, Courtney Derosia, Tracy Caravella, R. Daniel Duquette 

Calif J Health Promot 2006

Tai Chi Chih acutely decreases sympathetic nervous system activity in older adults.
Motivala SJ1, Sollers J, Thayer J, Irwin MR.

J Gerontol A Biol Sci Med Sci. 2006 Nov;61(11):1177-80.

Shingles Immunity and Health Functioning in the Elderly: Tai Chi Chih as a Behavioral Treatment.
Irwin M, Pike J, Oxman M.
Evid Based Complement Alternat Med. 2004 Dec;1(3):223-232. Epub 2004 Dec 1.

Effects of a behavioral intervention, Tai Chi Chih, on varicella-zoster virus specific immunity and health functioning in older adults.
Irwin MR1, Pike JL, Cole JC, Oxman MN.

Psychosom Med. 2003 Sep-Oct;65(5):824-30.

Siddarth P, Abikenari M, Grzenda A, Cappelletti M, Oughli H, Liu C, Millillo MM, Lavretsky H. Inflammatory Markers of Geriatric Depression Response to Tai Chi or Health Education Adjunct Interventions. Am J Geriatr Psychiatry. 2023 Jan;31(1):22-32. doi: 10.1016/j.jagp.2022.08.004. Epub 2022 Aug 27. PMID: 36175271. https://pubmed.ncbi.nlm.nih.gov/36175271/

Kilpatrick LA, Siddarth P, Milillo MM, Krause-Sorio B, Ercoli L, Narr KL, Lavretsky H. Impact of Tai Chi as an adjunct treatment on brain connectivity in geriatric depression. J Affect Disord. 2022 Oct 15;315:1-6. doi: 10.1016/j.jad.2022.07.049. Epub 2022 Jul 26. PMID: 35905792; PMCID: PMC10182814. https://pubmed.ncbi.nlm.nih.gov/35905792/

Lavretsky H, Milillo MM, Kilpatrick L, Grzenda A, Wu P, Nguyen SA, Ercoli LM, Siddarth P. A Randomized Controlled Trial of Tai Chi Chih or Health Education for Geriatric Depression. Am J Geriatr Psychiatry. 2022 Mar;30(3):392-403. doi: 10.1016/j.jagp.2021.07.008. Epub 2021 Jul 30. PMID: 34404606; PMCID: PMC10208421 https://pubmed.ncbi.nlm.nih.gov/34404606/

Kilpatrick, L.A., Krause-Sorio, B., Siddharth, P., Mililo, M.M., Ercoli, L. Narr, K.L., Lavretsky, H. Impact of Tai Chi on global connectivity in geriatric depression. Am J Geriatr Psychiatry. 2021, April ;29(4):5106-5107. doi: https://doi.org/10.1016/j.jagp.2021.01.103

Laird KT, Krause B, Funes C, Lavretsky H. Psychobiological factors of resilience and depression in late life. Transl Psychiatry. 2019 Feb 14;9(1):88. doi: 10.1038/s41398-019-0424-7. PMID: 30765686; PMCID: PMC6375932. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375932/ , https://pubmed.ncbi.nlm.nih.gov/30765686/

Complementary Use of Tai Chi Chih Augments Escitalopram Treatment of Geriatric Depression: A Randomized Controlled Trial.
Lavretsky H1, Alstein LL, Olmstead RE, Ercoli LM, Riparetti-Brown M, Cyr NS, Irwin MR.

Am J Geriatr Psychiatry 2011;19:839–850.

Blood pressure, salivary cortisol, and inflammatory cytokine outcomes in senior female cancer survivors enrolled

in a tai chi chih randomized controlled trial. Campo RA1, Light KC, O'Connor K, Nakamura Y, Lipschitz D, LaStayo PC, Pappas LM, Boucher KM, Irwin MR, Hill HR, Martins TB, Agarwal N, Kinney AY.

J Cancer Surviv 2015; 9:115–125.

Laird KT, Paholpak P, Roman M, Rahi B, Lavretsky H. Mind-Body Therapies for Late-Life Mental and Cognitive Health. Curr Psychiatry Rep. 2018 Jan 25;20(1):2. doi: 10.1007/s11920-018-0864-4. PMID: 29372339. https://pubmed.ncbi.nlm.nih.gov/29372339/